Evidence for interleukin-5 in nasal polyps in aspirin-induced asthma
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چکیده
منابع مشابه
Evidence for interleukin-5 in nasal polyps in aspirin-induced asthma
Aspirin-induced asthma is often accompanied by nasal polyps, in which tissue eosinophils are abundant and activated. However, the mechanism of eosinophil infiltration remains unknown. We encountered two aspirin-induced asthma patients with nasal polyps and investigated eosinophil infiltration into nasal polyp tissue. Eosinophil chemotactic activity of extracts from the nasal polyp was elevated ...
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100% and pansinusitis. They needed antibiotic scheme. At 2 years in 83.3% had a VAS.7. At 58.3% had pansinusitis. The bronchial relapse did not increase. We determined the presence of VAS. 7 and pansinusitis (OR 1⁄4 4). The bronchial relapse did not influence with increasing VAS (OR 1⁄4 1). Conclusions: Nasal symptoms persistent were secondary to the nasal polyps and pansinusitis with higher le...
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Chronic rhinosinusitis with nasal polyps (CRSwNP) and asthma frequently coexist and are always present in patients with aspirin exacerbated respiratory disease (AERD). Although the pathogenic mechanisms of this condition are still unknown, AERD may be due, at least in part, to an imbalance in eicosanoid metabolism (increased production of cysteinyl leukotrienes (CysLTs) and reduced biosynthesis...
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BACKGROUND Urinary leukotriene E4 (LTE4) is a well-validated marker of the cysteinyl leukotriene pathway, and LTE4 elevation has been described in conditions such as asthma, aspirin sensitivity, and chronic rhinosinusitis (CRS). There have been a number of reports investigating the role of spot urine LTE4 to predict aspirin sensitivity; however, variability in urinary LTE4 may affect the accura...
متن کاملMontelukast protects against nasal lysine-aspirin challenge in patients with aspirin-induced asthma.
Aspirin-induced asthma (AIA) is associated with increased production of cysteinyl leukotrienes (CysLT). Although leukotriene CysLT1-receptor antagonists improve lower airway outcomes in AIA, their effects and dose-response in the upper airway is less well documented. The present study evaluated the dose-response for montelukast (ML) against nasal lysine-aspirin challenge in patients with AIA. A...
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ژورنال
عنوان ژورنال: Allergology International
سال: 1997
ISSN: 1323-8930
DOI: 10.2332/allergolint.46.161